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ORTHOFLEX® one//Natural cross linked hyaluronate. The only single injection.

Prefilled syringes|


A new generation of viscosupplement





Natural Cross-linked Hyaluronate 60 mg +  Chondroitin Sulfate 90mg / 3ml

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  • ORTHOFLEX one® is single treatment , viscoelastic gel injectable prefilled syringe used intra articular for treating arthritis. It is similar to synovial fluid, a substance that occurs naturally in the joints, synovial fluid acts as a lubricant and shock absorber.

  • ORTHOFLEX one® is cross~linked hyaluronate 60mg/3ml solution of highly purified sodium hyaluronate + chondroitin sulfate 90mg/3ml, with high molecular weight that guarantees its excellent efficiency and a strong therapeutic effect (3,0 million daltons).

  • Obtained by bio fermentative process, synthetic origin gives a complete safety eliminating any allergic reactions.

  • ORTHOFLEX one®  is a prefilled syringes having aluminum blister for sealing that assure 3 years guarantee of validity , sterilized by autoclave,



Chondroitin Sulfate and Hyaluronic Acid with ORTHOFLEX one® in the treatment of degenerative joint disease.


  • Hyaluronan contributes to the synovial fluid’s lubricating properties and also controls fluid flow into and out of the joint space.

  • Injected into knee joints with osteoarthritis (OA) to ease pain and stiffness. Chondroitin sulfate, is a structural component of aggrecan in cartilage and provides much of its resistance to compression.

  • Chondroitin sulfate (CS) and hyaluronic acid (HA) induces cartilage destruction and acts as a mediator of the inflammatory response.

  • Using Chondroitine Sulfate as a cross-linking agent increase biocompatibility and biodegradability native polymer and creates premises delay of cartilage degeneration and even supports   regeneration cartilage structure.

  • ORTHOFLEX one® –improved by cross linking , preponderantly elastic, confers capacity mechanic protection increased and improved lubrication( ≥45Pa characteristic human synovial fluid)



The treatment consists in administration of intra-articular single treatment : 


  • ORTHOFLEX one® is indicated for the symptomatic treatment of mild of severe osteoarthritis.

  • Orthoflex one is recommended for patients that have joints pain coupled with reduced mobility. These symptoms can occur as a result of degenerative disease or trauma.

  • ORTHOFLEX one® treats pain and restricted mobility and elasticity , protect cartilage as a result of   traumatic pathology in the knee joint and other synovial joints( hip, ankle, shoulder, elbow, wrist, fingers, toes, and the temporomandibular and facet joints)

  • Is also indicated for the reduction of post–arthroscopy pain.

  • Is contraindicated in children, pregnant or breast–feeding women.

Physicochemical Properties:


The treatment consists in administration of intra-articular single treatment : 


  • Treatment  1injection

  • 60mg/3ml (2%) sodium hyaluronate

  • 90mg/3ml chondroitin sulfate

  • Average molecular weight 3 million Daltons (viscometric data)

  • Elasticity minimum 110 Pa (2.5Hz, maximum effort)

  • Viscosity minimum  45 Pa (2.5Hz, maximum effort)

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